When life gets busy (or my curiosity gene kicks in), it can be hard to focus on what's really important. As you've seen before (see "Related items" at the end of this post), I often turn to tools like PowerPoint and Mind Manager to make my life easier.
As for focusing on priorities, I have found that PowerPoint's "Smart Art" tools are particularly useful for creating a "Top 3 Focus Areas" list each month. On this one-page cue, I add my top 3 focus areas, and my top 3 desired outcomes for each. Essentially, these become my "must get done" items for the month.
I then print out the page, carry it around with me and make notes on the page to help track my progress, update my boss & peers, etc.
This is amazingly simple and very effective. I happen to use PowerPoint 2007, which has some snazzy templates (I often change them around just to make life more interesting - a couple of examples are shown here).
Give it a try, and see if it helps you focus.